{"id":2933,"date":"2020-06-06T16:15:14","date_gmt":"2020-06-06T15:15:14","guid":{"rendered":"https:\/\/bio-pat.org\/?p=2933"},"modified":"2021-10-18T17:26:25","modified_gmt":"2021-10-18T16:26:25","slug":"knauer-praesentiert-simulated-moving-bed-chromatography","status":"publish","type":"post","link":"https:\/\/bio-pat.org\/en\/knauer-praesentiert-simulated-moving-bed-chromatography","title":{"rendered":"KNAUER pr\u00e4sentiert “Simulated Moving Bed Chromatography”"},"content":{"rendered":"

KNAUER pr\u00e4sentiert “Simulated Moving Bed Chromatography”<\/strong><\/p>\n

Dr. Paul Pietsch <\/span>von der KNAUER Wissenschaftlichen Ger\u00e4te GmbH<\/a> pr\u00e4sentiert das Prinzip der “Simulated Moving Bed Chromatographie” (SMBC) in diesem Video<\/a>.
\nKNAUER ist auch treues Mitglied im Netzwerk Bio-PAT<\/a>.<\/p>\n

Die Anzahl an chromatographischen Aufreinigungsschritten in der Pharma und Life Science Industrie ist kontinuierlich angestiegen. Die “Simulated Moving\u00a0Bed Chromatographie” kann helfen, den Bedarf an hoher Produktivit\u00e4t zu bedienen. SMBC wird daher zunehmend als Trenntechnik in der pharmazeutischen Industrie, der Herstellung von Feinchemikalien und auf dem Gebiet des Bioengineering eingesetzt.<\/p>\n

\"KNAUER
Beispiel Azura SMBC<\/figcaption><\/figure>\n
\n
\n

SMBC ist eine Methode der Prozess-Chromatografie, die es erm\u00f6glicht, Stoffgemische kontinuierlich zu trennen und in zwei Fraktionen zu extrahieren. Ihr Wirkungsgrad ist durch eine bessere Ausnutzung der S\u00e4ulen (kontinuierlicher Betrieb) <\/span>deutlich h\u00f6her als bei Batch-HPLC.<\/p>\n

Auch wenn der einzelne Prozess auf zwei Fraktionen beschr\u00e4nkt ist, so kann durch Kopplung mehrerer SMB-Prozesse prinzipiell jede Teilfraktion in eine weitere Fraktion zerlegt werden – bis schlie\u00dflich das finale bin\u00e4re Stoffgemisch getrennt werden kann. Ausbeute und Reinheit der Trennung des bin\u00e4ren Stoffgemisches k\u00f6nnen dabei bis zu 100% erreichen. Ebenso k\u00f6nnen bis zu 90% des L\u00f6sungsmittels eingespart werden und die Zielsubstanz wird weitaus weniger verd\u00fcnnt als bei der Batch-HPLC.<\/span><\/p>\n

Typischerweise wird der SMB-Prozess bei Zweikomponenten-Gemischen genutzt, aus dem beide Substanzen direkt in reiner Form extrahiert werden. Ideal ist dies beispielsweise auf chirale Trennungen anwendbar oder solche Chromatogramme, in denen ein “f\u00fchrender” oder “nachlaufender” Produktpeak vorhanden ist.<\/p>\n

AZURA SMB Systeme k\u00f6nnen wegen ihres modularen Aufbaus auch f\u00fcr andere Mehrs\u00e4ulenverfahren konfiguriert werden. KNAUER bietet SMB-Systeme bis zum Ma\u00dfstab von 1000 kg\/Jahr an. Mehr Informationen zur SMB-Chromatographie: <\/span>https:\/\/www.knauer.net\/smb<\/a>.<\/p>\n


\n(Quellen & Fotos\u00a9: KNAUER Wissenschaftliche Ger\u00e4te GmbH<\/a>, Beitrag KNAUER LinkedIn<\/a>)<\/em> <\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

KNAUER pr\u00e4sentiert “Simulated Moving Bed Chromatography” Dr. Paul Pietsch von der KNAUER Wissenschaftlichen Ger\u00e4te GmbH pr\u00e4sentiert das Prinzip der “Simulated Moving Bed Chromatographie” (SMBC) in diesem Video. KNAUER ist auch […]<\/p>\n","protected":false},"author":3,"featured_media":2950,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2933","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"featured_image_src":{"landsacpe":["https:\/\/bio-pat.org\/wp-content\/uploads\/2020\/06\/Knauer-Video-SMB-HPLC-1000x445.png",1000,445,true],"list":["https:\/\/bio-pat.org\/wp-content\/uploads\/2020\/06\/Knauer-Video-SMB-HPLC-463x348.png",463,348,true],"medium":["https:\/\/bio-pat.org\/wp-content\/uploads\/2020\/06\/Knauer-Video-SMB-HPLC-300x150.png",300,150,true],"full":["https:\/\/bio-pat.org\/wp-content\/uploads\/2020\/06\/Knauer-Video-SMB-HPLC.png",1000,500,false]},"yoast_head":"\nKNAUER pr\u00e4sentiert "Simulated Moving Bed Chromatography" - Bio-PAT<\/title>\n<meta name=\"description\" content=\"KNAUER pr\u00e4sentiert "Simulated Moving Bed Chromatography" online in einem Video auf YouTube. 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