{"id":9528,"date":"2023-05-16T21:33:52","date_gmt":"2023-05-16T20:33:52","guid":{"rendered":"https:\/\/bio-pat.org\/?p=9528"},"modified":"2023-07-27T12:03:07","modified_gmt":"2023-07-27T11:03:07","slug":"launch-of-fyonibios-choflow-technology","status":"publish","type":"post","link":"https:\/\/bio-pat.org\/en\/launch-of-fyonibios-choflow-technology","title":{"rendered":"Launch of FyoniBio\u2019s CHOFlow\u00ae technology"},"content":{"rendered":"\n<p class=\"has-normal-font-size wp-block-paragraph\"><strong>Launch of FyoniBio\u2019s CHOFlow\u00ae technology &#8211; Enhanced Potency meets Outstanding Manufacturability<\/strong><\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">The new CHOFlow\u00ae technology of the <a href=\"http:\/\/www.fyonibio.com\" target=\"_blank\" rel=\"noreferrer noopener\">FyoniBio GmbH<\/a> for the high yield production of afucosylated ADCC enhanced antibodies was successfully launched in May 2023. <\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\"><a href=\"https:\/\/www.fyonibio.com\/wp-content\/uploads\/2023\/05\/PR_CHOFlow_230517.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Press Release:<\/a><\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">May 16, 2023<br><strong>Berlin, Germany: <\/strong>FyoniBio is expanding its broad panel of different tailored cell lines by its newCHOFlow\u00ae technology. The new cell line unifies excellent productivity rates and exceptionally stable and robust production processes of our CHOnamite\u00ae host cell line with a proven genetic glyco-engineering strategy to eliminate the core fucose on antibodies as well as other glycoproteins. This allows FyoniBio to develop high yield cell lines that produce our customer&#8217;s monoclonal antibody candidates with enhanced antibody dependent cellular cytotoxicity (ADCC) effector function to have the potential to improve the therapeutic efficacy of the monoclonal antibodies as well as reduce dosing requirements.<\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">Beyond the well-known effect on the ADCC activity on antibodies against cancer targets novel application fields come into play like infectious disease, immuno-oncology or autoimmune applications.<\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">\u201cWe are very excited about this new addition to our already broad spectrum of CHO and GEX\u00ae derived cell lines to enable our customers to start the biopharmaceutical development with the best possible cell line being it classical antibodies, bispecifics or other non-antibody proteins\u201d said Lars St\u00f6ckl, Managing Director of FyoniBio.<\/p>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\">By using a reference monoclonal antibody, the CHOFlow\u00ae technology has been shown to result in clones with productivities &gt;5 g\/L with excellent stability of the cell line as well as quality of the produced monoclonal antibody in a short timeline.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FyoniBio is a member of the network <a href=\"https:\/\/bio-pat.org\" target=\"_blank\" rel=\"noreferrer noopener\">Bio-PAT<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Launch of FyoniBio\u2019s CHOFlow\u00ae technology &#8211; Enhanced Potency meets Outstanding Manufacturability The new CHOFlow\u00ae technology of the FyoniBio GmbH for the high yield production of afucosylated ADCC enhanced antibodies was [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":9529,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9528","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein"],"featured_image_src":{"landsacpe":["https:\/\/bio-pat.org\/wp-content\/uploads\/2023\/06\/Abbildung_News_CHO_Launch-768x512-1-768x445.jpg",768,445,true],"list":["https:\/\/bio-pat.org\/wp-content\/uploads\/2023\/06\/Abbildung_News_CHO_Launch-768x512-1-463x348.jpg",463,348,true],"medium":["https:\/\/bio-pat.org\/wp-content\/uploads\/2023\/06\/Abbildung_News_CHO_Launch-768x512-1-300x200.jpg",300,200,true],"full":["https:\/\/bio-pat.org\/wp-content\/uploads\/2023\/06\/Abbildung_News_CHO_Launch-768x512-1.jpg",768,512,false]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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