This is a special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section „Biochemical Engineering„.
Special Issue Information
The consistent development of new bioprocesses needs to be performed at the perspective of the final process scale. Therefore, an efficient bioprocess development should consider large‑scale effects and integrate them from early stages onwards together with process analytical technologies (PAT) and quality by design (QbD). This includes technical challenges (sensors, modelling), the cellular dynamic regulatory networks and population dynamics. Current progresses in automation and parallelization demand for a higher degree of digitalization and advanced data treatment.
The aim of this Special Issue is to discuss the efficiency of the whole product and process life cycle, from the raw materials and early screening stages to industrial scale production and final application. This Special Issue is a joint project of the journals Microorganisms and Bioengineering and focuses on contributions at the 6th BioProScale Symposium and 7th BioProScale Symposium, which were organized as a digital event from 29–31 March 2021 and 28–31 March 2022, but further contributions are also invited on the following subjects:
Industrial-scale bioprocessing (scale-down and scale-up approaches, industrial-scale operation, population heterogeneity, process monitoring and advanced control, modelling of industrial-scale processes, mixing and reactor characterization, process robustness and repeatability, integrated upstream and downstream operations),
process analytical technologies (PAT, multiparameter analysis, non-invasive sensors, single-cell based monitoring, soft sensors, fault identification and diagnosis, multiposition measurements, data handling and exploration, monitoring and control of co- and mixed cultures),
high-throughput bioprocessing and automation (lab automation and robotics, automated screenings in bioprocess development, DoE, model‑based experimental designs, algorithm based operations and operational space characterisation, evolutionary strategies for strains and processes, communication trends for dynamic device operation and data flow, high-throughput strain engineering) and
bioprocesses for a circular economy (waste streams to value-added products, pretreatment, feedstock flexibility, scale-up/scale-down of biorefinery concepts, closed carbon cycles, smart bioproduction grids, decentralised production).
The papers related to microbiology are welcome for Microorganisms, related to engineering and other fields are welcome for Bioengineering. The Joint Special Issue in Microorganisms: Strategies for the Efficient Development of Microbial Bioprocesses
Special Issue Editors
Prof. Dr. Peter Neubauer Website
Guest Editor
Department of Bioprocess Engineering, Technische Universität Berlin, Ackerstraβe 76, ACK24, D-13355 Berlin, Germany and member of the Bio-PAT Network
Interests: bioprocess development; Escherichia coli physiology; recombinant proteins; cocultivation; fed-batch; continuous culture
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Christoph Herwig Website
Guest Editor
Department of Chemical Engineering, Research Area Biochemical Engineering, Vienna University of Technology, 1040 Vienna, Austria
Interests: integrated bioprocess development; monitoring; modeling and control of bioprocesses; data–information–knowledge; scale down models
Special Issues, Collections and Topics in MDPI journals
Deadline for manuscript submissions: 30 September 2023
Information for Manuscript submission
