BioProScale Symposium 2021: Scale-up and scale-down
29. März 2021 ; 13:00 – 31. März 2021 ; 16:30
More information about the BioProScale Symposium 2021 will follow on the website.
Scale-up and scale-down for accelerated bioprocess development and optimisation
The BioProScale Symposium 2021 is targeted at experts from research & development and industrial practice in the industrial bioprocessing of pharmaceuticals, food, feed and renewables. Consistent development of new bioprocesses needs to be performed at the perspective of the final process scale. Therefore an efficient bioprocess development should consider large scale effects and integrate them from early stages onwards together with PAT and QbD. This is one important aim of the network Bio-PAT.
It includes technical challenges (sensors, modelling), the cellular dynamic regulatory networks and population dynamics. Current progresses in automation and parallelization demand for a higher degree of digitalization and advanced data treatment. The aim is to discuss the efficiency of the whole product and process life cycle, from the raw materials and early screening stages until industrial-scale production and final application.
- Industrial-Scale Bioprocessing
(Scale-down and scale-up approaches, industrial-scale operation, population heterogeneity, process monitoring and advanced control, modelling of industrial-scale processes, mixing and reactor characterization, process robustness and repeatability, integrated upstream and downstream operations)
- Process Analytical Technologies (PAT)
(Multiparameter analysis, non-invasive sensors, single-cell based monitoring, soft sensors, fault identification and diagnosis, multiposition measurements, data handling and exploration, monitoring and control of co- and mixed cultures)
- High-Throughput Bioprocessing and Automation
(Lab automation and robotics, automated screenings in bioprocess development, DoE, model based experimental designs, algorithm based operations and operational space characterisation, evolutionary strategies for strains and processes, communication trends for dynamic device operation and data flow, high-throughput strain engineering)
- Single-use bioreactors and their applications / Cell culture technologies
(Reactor types from µl to m³, sensors for single-use processes, continuous processing, scalability, sustainability, modular manufacturing, microbial and mammalian / plant cell cultures)
- Bioprocesses for a Circular Economy
(Waste streams to value-added products, pretreatment, feedstock flexibility, scale-up / scale-down of biorefinery concepts, closed carbon cycles, smart bioproduction grids, decentralised production)
- Microsystems for Biotechnology
(Miniaturisation through microelectronics, physical sensors, biosensors, intelligent microwell plates, co-integration of microfluidics, lab-on-chip system)
Organizer: Technische Universität Berlin, Chair of Bioprocess Technology & Institute for Biotechnology and Fermentation in Berlin (IfGB)